Biochem/physiol Actions

pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively

Cell permeable: no

Reversible: no

Primary TargetJNK2 and JNK3

Product competes with ATP.

General description

A thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC₅₀ = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC₅₀﹤5.0). In contrast, SP600125 offers little selectivity between JNK1 and JNK3 (pIC₅₀ = 6.4 and 5.9, respectively) under the same assay conditions.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Angell, R.M., et al. 2007. Bioorg. Med. Chem. Lett.17, 1296.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)